New technology for API solubility

Continuous production of water soluble granules via Twin Screw Granulation

In collaboration with Ghent University, Labo Smeets has developed a technique to produce watersoluble granules; containing poorly water soluble drugs of Class II (poorly soluble, highly permeable) or Class IV (poorly soluble, poorly permeable) of the Bio Classification System (BCS).

The granulation technique – in combination with suitable excipiens as polyethyleneglycols and maltodextrins – improves the extent, but mainly the rate of dissolution of the poorly water soluble drug. The faster release of the API results often in an improved bioavailability and consequently a decreased intake of API to obtain the same clinical effect.

The technique can be applied for the production of human and veterinary medicines. Nowadays, the technique is used for the production of granules administered via drinking water to treat large groups of animals (poultry, pigs, …). The produced granules can also be filled in capsules or can be used as intermediates for the production of tablets.

The main advantages of the technique are the continuous process, the limited problems of upscaling and the absence of solvents by which no drying step is necessary.

The Twin Screw Granulator (Pharma TSG 24) is supplied by Thermo Scientific, an important player in the production of twin screw granulators and extruders. A picture of the Twin Screw Granulator is shown below.

The equipment is operational since January 2011.

Technology

LABORATORIA SMEETS N.V.

Fotografielaan 42
B-2610 Antwerpen-Wilrijk
Tel. +32 (0)3 828 29 37
Fax +32 (0)3 830 21 36
e-mail: info@labosmeets.be

EN  NL  FR  DE  ES 
CASE:  

Read more...

Read more...
New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make granules. The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients. This equipment is installed and available since January 2011.

Read more...
CASE: Flexibility  

We were contacted by a company that had a large project based upon nasal therapy with essential oils. There was no supplier for the part, no clear definition of the product and no procedure lines to make the product, but there was a short deadline. Pressure in order to obtain the right information at the right timing. We agreed with the customer the precise ...
Read more...
CASE: Packaging excellence  

A potential customer had set up an organization to import pharmaceutical products from lower priced markets into higher priced markets. As we have a lot of experience in setting up flexible packaging lines, we showed an interest in order to supply the relabeling and .repackaging of this product. A nice coincidence was that a particular company, which as active ...
Read more...
CASE: Product innovation  

A customer identified a patented technology at one of the Belgian universities to make one of their products easier to administer. We were contacted at an early stage to help with developing the product. We jointly decided to set up a test manufacturing unit in order to produce small batches for the clinical trials. As the project outcome was uncertain, ...
Read more...
CASE: Speed to market  

A customer found an opportunity to launch an anti-allergic product in one of its markets. The opportunity came up quickly, but the product design wasn’t ready, nor were the sales forecasts. The marketing team instructed to identify the swiftest supplier to realize the product launch. In less than 2 weeks, we were able to present a fully elaborated ...
Read more...