Cases

Back to overview

New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make highly soluble granules.

The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients.

The technology is applicable for the following drug classes:

  • Class II: poorly soluble, highly permeable
  • Class IV: poorly soluble, poorly permeable

The benefits of this technology speak for itself:

  • better bio-availability
  • faster release of the active ingredient
  • less active ingredient to produce the same effect
  • enabling chemicals tasteless and non-toxic
  • can be used for powders of capsules or tablets

The equipment is a Twin Screw Coextrusion ThermoFisher Scientific.

Typical enabling polymers are

  • PEG 300-5000
  • Maltodextrin
  • Xanthan gum

This equipment is installed and available since January 2011.

 



LABORATORIA SMEETS N.V.

Fotografielaan 42
B-2610 Antwerpen-Wilrijk
Tel. +32 (0)3 828 29 37
Fax +32 (0)3 830 21 36
e-mail: info@labosmeets.be

EN  NL  FR  DE  ES 
CASE:  

Read more...

Read more...
New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make granules. The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients. This equipment is installed and available since January 2011.

Read more...
CASE: Product innovation  

A customer identified a patented technology at one of the Belgian universities to make one of their products easier to administer. We were contacted at an early stage to help with developing the product. We jointly decided to set up a test manufacturing unit in order to produce small batches for the clinical trials. As the project outcome was uncertain, ...
Read more...
CASE: Speed to market  

A customer found an opportunity to launch an anti-allergic product in one of its markets. The opportunity came up quickly, but the product design wasn’t ready, nor were the sales forecasts. The marketing team instructed to identify the swiftest supplier to realize the product launch. In less than 2 weeks, we were able to present a fully elaborated ...
Read more...
CASE: Strategic procurement  

One of  our pharmacuetical customers is a large consumer of raw materials. Often large pharmaceutical customers are constrained with their raw materials procurement strategies. The complexity of the regulatory filing for many of their products, prevents them from obtaining the best deal. Underlying causes are the intrinsic speed of action, but also the ...
Read more...
CASE: International  

A potential customer outside the European Union contacted Laboratoria Smeets. He had obtained, sooner than expected, a registration for his powder product and was desperately seeking to be on the market as soon as possible. We immediately shared his sense of urgency. Just one day after the initial contact, we offered a full service proposal to buy the ...
Read more...