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New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make highly soluble granules.

The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients.

The technology is applicable for the following drug classes:

  • Class II: poorly soluble, highly permeable
  • Class IV: poorly soluble, poorly permeable

The benefits of this technology speak for itself:

  • better bio-availability
  • faster release of the active ingredient
  • less active ingredient to produce the same effect
  • enabling chemicals tasteless and non-toxic
  • can be used for powders of capsules or tablets

The equipment is a Twin Screw Coextrusion ThermoFisher Scientific.

Typical enabling polymers are

  • PEG 300-5000
  • Maltodextrin
  • Xanthan gum

This equipment is installed and available since January 2011.

 



LABORATORIA SMEETS N.V.

Fotografielaan 42
B-2610 Antwerpen-Wilrijk
Tel. +32 (0)3 828 29 37
Fax +32 (0)3 830 21 36
e-mail: info@labosmeets.be

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New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make granules. The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients. This equipment is installed and available since January 2011.

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