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New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make highly soluble granules.

The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients.

The technology is applicable for the following drug classes:

  • Class II: poorly soluble, highly permeable
  • Class IV: poorly soluble, poorly permeable

The benefits of this technology speak for itself:

  • better bio-availability
  • faster release of the active ingredient
  • less active ingredient to produce the same effect
  • enabling chemicals tasteless and non-toxic
  • can be used for powders of capsules or tablets

The equipment is a Twin Screw Coextrusion ThermoFisher Scientific.

Typical enabling polymers are

  • PEG 300-5000
  • Maltodextrin
  • Xanthan gum

This equipment is installed and available since January 2011.




LABORATORIA SMEETS N.V.

Fotografielaan 42
B-2610 Antwerpen-Wilrijk
Tel. +32 (0)3 828 29 37
Fax +32 (0)3 830 21 36
e-mail: info@labosmeets.be

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CASE: New Technology for API solubility  

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make highly soluble granules. The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients. The technology is applicable for the following drug ...
Read more...
New Technology for API solubility

In collaboration with the University of Ghent, Labo Smeets has realised a new process in pharmaceutical extrusion technology, which enables us to make granules. The main application is to make pharmaceutical granule compositions to drastically improve water solubility of active ingredients. This equipment is installed and available since January 2011.

Read more...
CASE: Flexibility  

We were contacted by a company that had a large project based upon nasal therapy with essential oils. There was no supplier for the part, no clear definition of the product and no procedure lines to make the product, but there was a short deadline. Pressure in order to obtain the right information at the right timing. We agreed with the customer the precise ...
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CASE: Packaging excellence  

A potential customer had set up an organization to import pharmaceutical products from lower priced markets into higher priced markets. As we have a lot of experience in setting up flexible packaging lines, we showed an interest in order to supply the relabeling and .repackaging of this product. A nice coincidence was that a particular company, which as active ...
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CASE: Strategic procurement  

One of  our pharmacuetical customers is a large consumer of raw materials. Often large pharmaceutical customers are constrained with their raw materials procurement strategies. The complexity of the regulatory filing for many of their products, prevents them from obtaining the best deal. Underlying causes are the intrinsic speed of action, but also the ...
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